Highway 321 is one of two exits for Newport TN, and also goes to Gatlinburg, and the Great Smoky Mountains National Park. NOTE; For highway travel via U.S. Highway #321 See Milebymile.com Road Map Highway Travel Guide - Junction of to I-75 to I-40(Near Newport) via Maryville, TN. and Gatlinburg, TN. for driving directions.
It's a little harder to reach than popular spots like Cades Cove because it's on the North Carolina side of the park. If you are coming from the north and places like Pigeon Forge, Gatlinburg and Sevierville, take Highway 321 north to Interstate 40, then east towards Asheville. Get off at exit 20 and take Cove Creek Road.